Researchers have uncovered an early disruption in the process of memory formation in older humans who exhibit some early brain changes associated with Alzheimer’s disease, but show little or no memory impairment.
The work sheds light on the role of amyloid protein in memory impairment and could lead to development of strategies for predicting and treating cognitive decline in individuals who are at-risk for Alzheimer’s disease.
Amyloid protein plays a major pathogenic role in Alzheimer’s disease, a devastating neurodegenerative disorder characterized by progressive cognitive impairment and memory loss. In fact, one of the primary characteristics of Alzheimer’s disease is the accumulation and deposition of neuron-damaging clumps of amyloid protein. Previous studies have led to the suggestion that amyloid deposition begins many years prior to the onset of clinical symptoms. However, the exact link between amyloid deposition and memory impairment has not been clearly demonstrated in humans.
Image: The beta-amyloid fragment is crucial in the formation of senile plaques in Alzheimer’s disease.
“Two recent advances in neuro-imaging now allow us to explore the early, asymptomatic phase of Alzheimer’s disease, the ability to measure amyloid distribution in living humans and the identification of sensitive markers of brain dysfunction in Alzheimer’s disease,” explains lead study author, Dr. Reisa Sperling. In addition to amyloid accumulation, Alzheimer’s disease has been associated with functional alterations in a specific network of brain regions that are intimately linked with memory formation.
Dr. Sperling and colleagues combined amyloid imaging with an associative memory functional brain imaging paradigm to study older humans who did not exhibit significant memory impairment. Importantly, the researchers found that a significant number of non-demented older individuals exhibited amyloid deposition and abnormal neural activity in key areas of the brain network thought to be involved in successful memory function. These results demonstrate for the first time that amyloid pathology in asymptomatic older humans is linked with aberrant neural responses during the process of memory formation.
“Longitudinal studies are certainly needed, but our findings are consistent with the premise that cognitively intact older individuals with amyloid pathology may already be in the early stages of Alzheimer’s disease,” explains Dr. Sperling. “The combination of molecular and functional imaging techniques may prove useful in monitoring disease progression prior to significant clinical symptoms, as well as the response to amyloid-modifying therapeutic agents in subjects at-risk for developing Alzheimer’s disease.”
References:
1. Reisa Sperling, et al. Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia . Neuron, Volume 63, Issue 2, 178-188.
