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Brain Areas Fail to Connect in ADHD
“This is the first time that we have direct evidence that this connectivity is missing in ADHD,” said researcher Ali Mazaheri.
The researchers made the discovery by analyzing the brain activity in children with ADHD.
They measured electrical rhythms from the brains of volunteers, especially the alpha rhythm. When part of the brain is emitting alpha rhythms, it shows that it is disengaged from the rest of the brain and not receiving or processing information optimally, Mazaheri said.
In the experiments, children with diagnosed ADHD and normal children were given a simple attention test while their brain waves were measured. The test consisted of being shown a red or blue image, or hearing a high or low sound, and having to react by pressing a button. Immediately before the test, the children were shown either a letter “V” to alert them that the test would involve a picture (visual), or an inverted “V” representing the letter “A” to alert them that they would hear a sound (auditory).
According to current models of how the brain allocates attention, signals from the frontal cortex — such as the “V” and “A” cues — should alert other parts of the brain, such as the visual processing area at the back of the head, to prepare to pay attention to something. That should be reflected in a drop in alpha wave activity in the visual area, Mazaheri said.
And that is what the researchers found in the brain waves of children without ADHD. But children with the disorder showed no such drop in activity, indicating a disconnection between the center of the brain that allocates attention and the visual processing regions.
“The brains of the children with ADHD apparently prepare to attend to upcoming stimuli differently than do typically developing children,” Mazaheri said.
Children with ADHD did improve their reaction times when properly cued, but they don’t seem to allocate resources as efficiently, he said.
This is the first evidence from brain electrical patterns for a functional disconnection in cortical attention systems in ADHD, he said. Current definitions of ADHD are based only on behavior.
The research was originally inspired by a desire to combine laboratory and clinical research to go beyond existing measures of ADHD and get a better understanding of the condition.
1. Ali Mazaheri, et al. Functional Disconnection of Frontal Cortex and Visual Cortex in Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry. doi:10.1016/j.biopsych.2009.11.022