According to researcher Elizabeth Gardner, an associate professor in the Department of Food Science and Human Nutrition, those who restrict calorie intake during flu season could have a harder time fighting off the flu virus.
In a study lead by Gardner, mice with a calorie-restricted diet were more likely to die during the first few days of infection than mice with a normal diet.
Caloric restriction is the practice of reducing the intake of calories to 40 percent of a normal diet, while maintaining adequate vitamins and minerals.
“If you are exposed to a new strain of influenza, to which your body has not made adequate antibodies to protect you from infection, your body must rely on cells that will kill the virus,” Gardner said. “The natural killer cells are important in controlling the early stages of virus infection, because they act quickly once they encounter virus-infected cells. Our studies show that calorically restricted mice have increased susceptibility to influenza, and their bodies are not prepared to produce the amount of natural killer cells needed to combat the stress of fighting an infection.”
Normally fed mice and calorie-restricted mice exposed to the influenza virus decreased food intake as they tried to fight off the infection. The calorie-restricted mice took longer to recover and exhibited increased mortality, weight loss and other negative effects. Even though both sets of mice had a vitamin-fortified diet, the normal diet mice regained their appetites back sooner and recovered faster.
“Our research shows that having a body ready to fight a virus will lead to a faster recovery and less-severe effects than if it is calorically restricted,” Gardner said. “Adults can calorically restrict their diet eight months out for the year, but during the four months of flu season they need to bump it up to be ready. You need the reserves so your body is ready for any additional stress, including fighting a virus.”
Flu shots can’t guarantee protection, in any case, since they are formulated months in advance and only can target a small handful of the many flu virus strains that might infect the population.
“If the strain of flu a person is infected with is different from the strain included in the flu vaccination, then your body sees this as a primary infection and must produce the antibodies to fight it off. A calorically restricted body is not as well prepared to do this and cannot control early infection, which impedes recovery,” Gardner added.
References:
1. Elizabeth Gardner, et al. Feed a cold, feed a fever. Michigan State University. November 2008.
2. Image by Dr. Erskine. L. Palmer, Dr. M. L. Martin. CDC.
