Inherited Impulsivity a Trait Predictive of Alcoholism

In a study appearing in Alcoholism journal, researchers report that genetic predisposition to impulsivity is a trait predictive of alcoholism.

Alcoholism is a disease and other research shows that the risk for developing alcoholism does indeed run in families. Researchers are working to discover the actual genes that put people at risk for alcoholism. Friends, the amount of stress, and how readily available alcohol is also are factors that may increase risk for alcoholism.

Nicholas Grahame and fellow researchers used selective breeding for 30 generations to produce mice who were high volume alcohol drinkers and others who avoided consuming alcohol. The genetically different mice were presented with a choice between a small, immediate reward and a large, delayed reward. By adjusting the quantity of the immediate reward up and down based on choice behavior, the task allowed the researchers to test the impulsivity of the rodents.

The mice with high alcohol preferring genes were more impulsive than their low drinking counterparts demonstrating that predisposition to impulsivity is predictive of alcoholism.

"Selective breeding allowed us to focus on whether changing genes changes behavior. Just like golden retrievers are bred to retrieve, we were able to breed mice genetically predisposed to drink alcohol voluntarily. Many drink enough to reach a blood alcohol level of .08," said Dr. Grahame, who is a behavioral geneticist.

In humans a blood alcohol level of .08 is produced by the consumption of two drinks an hour by a 120-pound individual or 3 drinks an hour by a 180-pound individual. At that level human concentration and judgment are impaired and all 50 states prohibit operation of a motor vehicle.

"It is well documented that humans with alcohol problems have impulsivity issues. High impulsivity, when defined as the tendency to choose small instantaneous rewards over larger delayed rewards, like getting drunk instead of going to work for that paycheck in 2 weeks, is more prevalent in alcoholics than in non-alcoholics. Because these mice had never had alcohol, we were able to show that it was the genes that increase drinking, rather than drinking itself, that yielded impulsive behavior," said Dr. Grahame.

"Our data can clearly be extrapolated to humans and strongly suggests that impulsivity contributes to high alcohol drinking. Consequently, the diagnosis of any disorder associated with impulsivity, such as attention deficit disorder or bipolar disorder, is cause for concern about future problems with alcoholism," he added.

The study was funded by the IUPUI School of Science and the National Institute on Alcohol Abuse and Alcoholism.

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References:
1. Nicholas Grahame, et al. High Alcohol Preferring Mice Are More Impulsive than Low Alcohol Preferring Mice as Measured in the Delay Discounting Task. Indiana University.
2. National Institute on Alcohol Abuse and Alcoholism.
3. Image by baltazarart