Researcher Identifies Key Contributor in Development of Alzheimer's

Walter J. Lukiw, PhD, Associate Professor of Neuroscience and Ophthalmology at Louisiana State University Health Sciences Center in New Orleans, is the lead author of a paper identifying, for the first time, a specific function of a fragment of ribonucleic acid (RNA), once thought to be no more than a byproduct, in regulating inflammation and the development of Alzheimer's.

Dr. Lukiw has shown that this tiny piece of RNA, or microRNA, called miRNA-146a is found in increased amounts in stressed human brain cells and in Alzheimer's, and that it plays a crucial role in the regulation of inflammation and disease-related neuropathology thought to be integral to the Alzheimer's process. Dr. Lukiw's research team demonstrated in human brain cells in primary culture that MiRNA-146a targets the messenger RNA of an important anti-inflammatory regulator called complement factor H (CFH). Testing both control cells and Alzheimer's disease-affected tissues, they found that miRNA-164a appears to reduce the amount and bioavailability of CFH, promoting the inflammation of brain cells and contributing to the development of Alzheimer's disease.

The most common form of dementia, Alzheimer's is a fatal, age-related neurodegenerative disorder characterized clinically by the progressive erosion of cognition and memory, and neuropathologically by defective gene expression and increased inflammatory cell signaling. According to the Alzheimer's Foundation of America, it is estimated that Alzheimer's currently affects more than 5 million Americans and it is projected that the number could more than triple to 16 million by mid-century.

"The goal of these neuroscience research studies is to further our understanding of the molecular biology and genetic mechanisms associated with Alzheimer's and to advance the design of therapeutic strategies to counteract this common and tragic neurological disorder," said Dr. Lukiw.
Source:
Walter J. Lukiw, et al. An NF-kB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer's and in stressed human brain cells. Louisiana State University Health Sciences Center. November 2008.

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