Psoriasis Associated With Cardiovascular Disease

According to research, the skin disease psoriasis is associated with atherosclerosis (a buildup of plaque in the arteries) characterized by an increased prevalence of ischemic heart disease, cerebral vascular disease and peripheral artery disease.

Psoriasis affects nearly 2 percent to 3 percent of the world's population, including 7 million Americans. In addition to its effects on the skin, psoriasis is associated with arthritis, depression and a lower quality of life. "More recently, psoriasis has also been shown to be a systemic inflammatory condition, with similarities to other inflammatory immune disorders," the authors write. "Since the risk of myocardial infarction is increased in rheumatoid arthritis and systemic lupus erythematosus, which are both inflammatory conditions, attention has been focused on the association between psoriasis, cardiovascular risk factors and myocardial infarction."

Srjdan Prodanovich and colleagues analyzed the computerized records of 3,236 psoriasis patients and 2,500 individuals without psoriasis who were seen at the same Veterans Administration facility. Patients in the psoriasis group were slightly older than those in the control group without psoriasis (average age 67.9 vs. 65.1) and were more likely to be men (95.5 percent vs. 88.2 percent).

"After age, sex and history of hypertension, diabetes, dyslipidemia [abnormal cholesterol levels] and smoking status were controlled for, patients with psoriasis were significantly more likely than controls to carry a diagnosis of atherosclerosis," the authors write. Patients with psoriasis were also more likely to have an additional diagnosis of another blood vessel disease, including ischemic heart disease (affecting vessels leading to the heart), cerebral vascular disease (vessels leading to the brain) or peripheral arterial disease (vessels outside the heart and brain).

Future studies should investigate whether treatment of either cardiovascular risk factors or psoriasis will lead to an improvement in atherosclerosis in these patients, the authors conclude. "In the meantime, we recommend that health care providers who are caring for patients with psoriasis be vigilant with respect to traditional risk factor screenings," they write.

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References:
1. Srjdan Prodanovich, et al. Psoriasis associated with cardiovascular disease and increased mortality. Arch Dermatol. 2009;145[6]:700-703.
2. Image by mysiann.