Researchers have shown the first time a link between an anti-aging gene and high blood pressure, offering new clues on how we age and how we might live longer.

Persistent hypertension, or high blood pressure, is a risk factor for stroke, heart attack, heart failure, arterial aneurysm and is the leading cause of chronic kidney failure. Even a modest elevation of arterial blood pressure leads to shortened life expectancy.

The researchers, led by Zhongjie Sun, tested the effect of an anti-aging gene called klotho on reducing high blood pressure. They found that by increasing the expression of the gene in rats with high blood pressure, they not only stopped blood pressure from continuing to rise, but succeeded in lowering it. Perhaps most impressive was the complete reversal of kidney damage, which is associated with prolonged high blood pressure and often leads to kidney failure.

"One single injection of the klotho gene can reduce high blood pressure for at least 12 weeks and possibly longer. Klotho is also available as a protein and, conceivably, we could ingest it as a powder much like we do with protein drinks," said Sun.

Scientists have been working with the klotho gene and its link to aging since 1997 when it was discovered by Japanese scientists. This is the first study showing that a decline in klotho protein level may be involved in the progression of high blood pressure and kidney damage, Sun said. With age, the klotho level decreases while the prevalence of high blood pressure increases.

Researchers used one injection of the klotho gene in hypertensive research models and were able to markedly reduce blood pressure by the second week. It continued to decline steadily for the length of the 12 week project. The klotho gene was delivered with a safe viral vector that is currently used for gene therapy.

Researchers are studying the gene's effect for longer periods to test its ability to return blood pressure levels to normal. They also are looking at whether klotho can prevent high blood pressure.

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References:
1. Zhongjie Sun, et al. Klotho Gene Delivery Prevents the Progression of Spontaneous Hypertension and Renal Damage. Hypertension, doi: 10.1161/HYPERTENSIONAHA.109.134320.

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