Gene Counteracts Effects of Protein Plaques in Alzheimer’s Disease

Understanding the function of the proteins that are linked to Alzheimer’s disease could shed light on how to prevent the formation of protein plaques in the brain and neurodegeneration. New research has shown that a particular gene, called Hes1, prevents some of the harmful effects of the protein amyloid beta, which forms plaques in the… [Continue Reading]

Proteins Identified to Play a Role in Plaque Formation in Alzheimer’s Disease Models

Plaques of a certain protein, called amyloid beta, are characteristic of Alzheimer’s disease, but whether these are a cause or consequence of the condition is still debated in the scientific community. Research focused on how the plaques form could resolve this issue, and new work has shown that an additional protein may play a key… [Continue Reading]

Alzheimer’s Disease Symptoms Can Be Reversed in Mouse Model

A loss of the ability to smell is one of the first signs of Alzheimer’s disease, and researchers have now shown the link between small plaques in the brain and the symptom. In a mouse model of Alzheimer’s, a drug that breaks up protein plaques was able to reverse the mice’s loss of smell. Researchers… [Continue Reading]

Gene Mutations Impair Ability to Remove Toxic Proteins in Alzheimer’s

Researchers have discovered how mutations in the presenilin 1 gene cause early-onset Alzheimer’s disease. The presenilin gene is most commonly associated with the early-onset familial form of Alzheimer’s, which runs in families and can strike people in their 30s.

Study Provides New Insights into Mechanisms of Alzheimer’s Disease

A study has provided new insights into the loss of structure in regions of the brain and its potential association with Alzheimer’s disease. The findings suggest a build-up of deposits of the protein amyloid-beta in a region of the brain known as the temporal inferior cortex.

Computer Simulation Created of Protein Malfunction in Alzheimer’s

Researchers have created a computer modeling of the structural malfunctioning of the ApoE4 protein when it enters into contact with the Amyloid beta molecule, the main cause of Alzheimer’s disease.

Calcium Waves Could Provide Insights Into Alzheimer’s Disease

New insights on what causes Alzheimer’s disease could arise from a recent discovery made by bioengineers from the University of California, San Diego. The finding concerns the infamous amyloid beta peptides (A?)-fragments of which form plaques thought to play a role in Alzheimer’s disease.

PET Imaging Provides Opportunity for Alzheimer’s Disease Testing

Current Alzheimer’s disease research indicates that accumulation of amyloid-beta (A?) protein plaques in the brain is central to the development of Alzheimer’s disease. Unfortunately, presence of these plaques is typically confirmed only at autopsy.

Study May Shake the Foundations of Alzheimer’s Disease Research

Alzheimer’s disease is caused by the build-up of a brain peptide called amyloid-beta, and the focus of almost all drug research pursuing a cure for Alzheimer’s disease has been to eliminate amyloid-beta. But that may be counterproductive, as recent research demonstrates that amyloid-beta is also necessary to maintain proper brain functioning. These findings may shake… [Continue Reading]

Green Tea Compound Could be Beneficial in Prevention of Alzheimer’s

Studies performed on genetically developed Alzheimer’s disease mice suggest that epigallocatechin-3-gallate (EGCG), a polyphenolic compound of green tea could be a beneficial agent in the prevention of or progression of Alzheimer’s disease. Alzheimer’s disease is characterized by the accumulation of amyloid plaques in the brain. Amyloid beta appears to be the main constituent of amyloid… [Continue Reading]