Parkinson’s disease is complex and difficult to study, given the complicated interactions between brain cells. A new model, however, is giving major new insights into what goes wrong in neurons in Parkinson’s patients. Scientists took skin cells from patients, and by changing their environmental signals in the laboratory, coaxed them into becoming neurons. Study of… [Continue Reading]
Model of Parkinson’s Disease Suggests New Approaches to Treatment
Research Sheds New Light on Parkinson’s Disease
An international collaboration led by academics at the University of Sheffield, has shed new light into Parkinson’s disease, which could help with the development of cures or treatments in the future. The collaboration, which was led by Professor Peter Redgrave from the University’s Department of Psychology, suggests that many of the problems suffered by patients… [Continue Reading]
Study Shows Brain Cells Abandon Mitochondria in Parkinson’s Disease
In a study that sheds new light on the causes of Parkinson’s disease, researchers report that brain cells in Parkinson’s patients abandon their energy-producing machinery, the mitochondria. A shutdown in fuel can have devastating effects on brain cells, which consume roughly 20 percent of the body’s energy despite making up only 2 percent of body… [Continue Reading]
Parkinson’s Patients at Risk for Falls When Talking While Walking
We’ve all heard the saying about people who can’t walk and chew gum at the same time, but it turns out that walking and talking is difficult enough, especially for people with Parkinson’s disease who are at increased risk for falls with injury. A new study found that older adults with Parkinson’s disease altered their… [Continue Reading]
Neuroimaging Identifies Patients Who Are at High Risk of Parkinson’s
REM sleep disturbances constitute an early marker of neurodegenerative diseases. This was demonstrated in an article published in 2006. A new study applies neuroimaging techniques to identify patients with REM sleep disturbances who will develop neurodegenerative disorders over the short term. One of the challenges of modern medicine is the diagnosis of diseases before they… [Continue Reading]
Researchers Explore Molecular Basis of Parkinson’s Disease Using Yeast
Dr Tiago Fleming Outeiro describes how his group is slowly uncovering the molecular basis of Parkinson’s disease by studying the associated human protein in yeast cells. Parkinson’s disease is a neurodegenerative disorder without any known cure that affects around 6 million people worldwide. The symptoms, which include rigidity, difficulty in initiating movements and resting tremors,… [Continue Reading]
Study a Step Towards Understanding the Aspects of Parkinson’s Disease
Researchers have found that people with Parkinson’s disease can perform automated tasks better than people without the disease, but have significant difficulty switching from easy to hard tasks. The findings are a step towards understanding the aspects of the illness that affect the brain’s ability to function on a cognitive level. “We often think of… [Continue Reading]
Parkinson’s Disease Genetic Link That Implicates the Immune System
A hunt throughout the human genome for variants associated with common, late-onset Parkinson’s disease has revealed a new genetic link that implicates the immune system. The long-term study involved a global consortium, including Johns Hopkins researchers from the Center for Inherited Disease Research (CIDR) who performed genome-wide association studies on more than 4,000 DNA samples… [Continue Reading]
Better Way to Grow Stem Cells on Synthetic Surfaces Developed
Human pluripotent stem cells, which can become any other kind of body cell, hold great potential to treat a wide range of ailments, including Parkinson’s disease, multiple sclerosis and spinal cord injuries. However, scientists who work with such cells have had trouble growing large enough quantities to perform experiments – in particular, to be used… [Continue Reading]
Stem Cells Successfully Used to Treat Parkinson’s Disease in Rodents
Researchers have successfully used human induced pluripotent stem cells (iPSCs) to treat rodents afflicted with Parkinson’s disease. The research, which validates a scalable protocol that the same group had previously developed, can be used to manufacture the type of neurons needed to treat the disease and paves the way for the use of iPSC’s in… [Continue Reading]