The Arthritis Research Campaign has launched the first evidence-based report dedicated to the use of complementary medicines in arthritis using results from randomized controlled trials. Complementary medicines are widely used by people with arthritis as they seek to avoid taking potentially harmful drugs, preferring natural products.
The purpose of the report is to provide a resource for patients and health care professionals by giving a summary of the current evidence on whether individual commonly used complementary medicines may be of use in the treatment of some types of arthritis and musculoskeletal conditions. The report focuses on the two most common forms of arthritis, namely rheumatoid arthritis and osteoarthritis as well as the chronic musculoskeletal pain disorder fibromyalgia.
Rheumatoid arthritis, the most common inflammatory arthritis, is a chronic disease that affects the joints, often those in a person’s wrists, fingers, and feet. Common symptoms of rheumatoid arthritis include pain, stiffness and fatigue.
Osteoarthritis is an extremely common disorder, increasing with age and is often referred to as “wear and tear” of the joints in the body. The surface of the joint is damaged and the surrounding bone grows thicker. The most common joints affected are those of the knees, hips, hands and spine.
Fibromyalgia is one of the most common reasons for being referred to a rheumatologist and the condition involves pain experienced all over the body accompanied by fatigue, sleep disturbance and tenderness to touch. The condition does not result in any damage to the joints or muscles that can explain the symptoms.
The report has only considered compounds which are taken orally (by mouth) or are applied to the skin, therapies such as acupuncture, chiropractic, massage and several others which have been commonly used for arthritis and musculoskeletal conditions have not been considered.
In evaluating compounds the report has relied heavily on data from randomized controlled trials. These are studies where patients are randomly allocated to one of the treatments being compared and then at the end of the study the results are evaluated according to whether patients, for example, on a new treatment had a better outcome than patients on an existing treatment.
The report has categorized each medicine into one of five categories:
-
There is, overall, no evidence to suggest that the compound works or only a little evidence which is outweighed by much stronger evidence that it does not work.
-
There is only a little evidence to suggest the compound might work. The evidence from studies in this category often come from only a single study which has reported positive results and there are therefore important doubts about whether or not it works.
-
There is some promising evidence to suggest that the compound works. The evidence will be from more than one study. However there may also be some studies showing that it does not work. Therefore we are still uncertain whether compounds in this category work or not.
-
There is some consistency to the evidence, which will come from more than one study, to suggest that the compound works. Although there are still doubts from the evidence that it works, on balance we feel that it is more likely to be effective than not.
-
There is consistent evidence across several studies to suggest that this compound is effective.
The report also categorized all compounds according to their safety profile. It should be emphasized that most conventional medicines have adverse effects, some serious.
The categorization the report has made on safety is as follows:
The categorization the report has made on safety is as follows:
-
Green. Compounds with reported adverse effects which are mainly minor symptoms and infrequent. A classification of Green does not mean that the compound has no reported adverse effects and patients should check in the product information leaflet what these are.
-
Amber. Compounds with adverse effects reported as common (even if they are mainly minor symptoms) or with more serious adverse effects.
-
Red. Compounds with serious adverse effects reported. Patients should carefully consider these before deciding whether to take these medicines
Below is a summary chart of products tested and score results, the full report can be downloaded free as a PDF from the Arthritis Research Campaign.
|
Product
|
Effectiveness Score
|
Safety
|
|
|
Anthocyanidins
|
Fibromyalgia
|
1
|
Amber
|
|
Antler velvet
|
Rheumatoid arthritis
|
1
|
Green
|
|
Articulin-F
|
Osteoarthritis
|
2
|
Green
|
|
Avocado-soybean unsaponifables (ASU)
|
Osteoarthritis
|
2
|
Green
|
|
Biqi capsule
|
Rheumatoid arthritis
|
2
|
Amber
|
|
Blackcurrant seed oil
|
Rheumatoid arthritis
|
1
|
Green
|
|
Borage seed oil
|
Rheumatoid arthritis
|
3
|
Green
|
|
Cannabis oral spray
|
Rheumatoid arthritis
|
2
|
Amber
|
|
Capsaicin gel
|
Osteoarthritis
Fibromyalgia |
5
2 |
Green
|
|
Cat’s claw
|
Rheumatoid arthritis
|
2
|
Amber
|
|
Cetylated fatty acids (CFAs)
|
Osteoarthritis
|
2
|
Green
|
|
Chondroitin
|
Osteoarthritis
|
3
|
Green
|
|
Collagen
|
Osteoarthritis |
2
1 |
Green
|
|
Devil’s claw
|
Osteoarthritis
|
3
|
Amber
|
|
Duhuo Jisheng Wan (DJW)
|
Osteoarthritis
|
2
|
Amber
|
|
Eazmov
|
Osteoarthritis
Rheumatoid arthritis |
1
|
Green
|
|
Evening primrose oil (EPO)
|
Rheumatoid arthritis
|
3
|
Green
|
|
Feverfew
|
Rheumatoid arthritis
|
1
|
Green
|
|
Fish oil:
Fish body oil Fish liver oil |
_
Rheumatoid arthritis Osteoarthritis |
_
5 1 |
Green
|
|
Flaxseed oil
|
Rheumatoid arthritis
|
1
|
Amber
|
|
Ginger
|
Osteoarthritis
|
3
|
Green
|
|
Gitadyl
|
Osteoarthritis
|
2
|
Green
|
|
Glucosamine:
Glucosamine sulphate Glucosamine hydrochloride |
Osteoarthritis
|
_
3 1 |
Green
|
|
Green-lipped mussel
|
Osteoarthritis
Rheumatoid arthritis |
3
1 |
Green
|
|
Homeopathy
|
Osteoarthritis
Rheumatoid arthritis Fibromyalgia |
1
1 2 |
Green
|
|
Indian frankincense
|
Osteoarthritis
|
3
|
Green
|
|
MSM
|
Osteoarthritis
|
2
|
Green
|
|
Phytodolor
|
Osteoarthritis
|
4
|
Green
|
|
Pine bark extracts
|
Osteoarthritis
|
3
|
Green
|
|
Reumalex
|
Osteoarthritis
Rheumatoid arthritis |
1
|
Green
|
|
Rosehip
|
Osteoarthritis
|
3
|
Green
|
|
SAMe
|
Osteoarthritis
|
4
2 |
Green
|
|
Selenium
|
Rheumatoid arthritis
|
1
|
Green
|
|
SKI _06X
|
Osteoarthritis
Rheumatoid arthritis |
3
2 |
Green
|
|
Stinging nettle
|
Osteoarthritis
|
1
|
Green
|
|
Thunder god vine
|
Rheumatoid arthritis
|
3
|
Red
|
|
Tong luo kai bi
|
Rheumatoid arthritis
|
1
|
Amber
|
|
Vitamins A,C,E (anti-oxidant vitamins)
|
Osteoarthritis
Rheumatoid arthritis |
2
1 |
Green
|
|
Vitamins D & B complex (non-anti-oxidant vitamins)
|
Osteoarthritis
|
2
|
Green
|
|
Willow bark
|
Osteoarthritis
Rheumatoid arthritis |
2
1 |
Amber
|
1. Arthritis Research Campaign.
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