A technique has been discovered that is able to determine whether a child has obstructive sleep apnea or habitual snoring by screening their urine.
“These findings open up the possibility of developing a relatively simple urine test that could detect obstructive sleep apnea in snoring children. This would alleviate the need for costly and inconvenient sleep studies in children who snore, only about 20 to 30 percent of whom actually have obstructive sleep apnea,” said lead author David Gozal.
The researchers studied 90 children who were referred to the sleep clinic to be evaluated for suspected sleep disordered breathing. They also recruited 30 healthy, non-snoring children from the community to serve as controls. The children all underwent standard overnight polysomnography and were categorized either as having obstructive sleep apnea, habitual snoring or no sleep disordered breathing.
The children’s first sample of urine was collected the morning after the sleep study. The researchers used a sophisticated electrophoresis technique to screen hundreds of proteins simultaneously and found that a number of the proteins were differently expressed in children with obstructive sleep apnea compared to children with habitual snoring or healthy, non-snoring children.
“It was rather unexpected that the urine would provide us with the ability to identify obstructive sleep apnea,” said Dr. Gozal. “However, the field of biomarkers is one that is under marked expansion and this certainly opens the way for possible simple diagnostic screening methods in the future.”
While it is estimated that one to three percent of all children up to the age of nine may suffer from obstructive sleep apnea, many more (up to 12 percent) experience habitual snoring. Because obstructive sleep apnea can lead to cognitive, behavioral, cardiovascular and metabolic consequences in children, differentiating it from habitual snoring is essential. The initial approach is surgical by removing the enlarged tonsils and adenoids, and some children may end up needing CPAP after their surgery.
“We wish to validate these findings in urine samples from many children from laboratories around the country and to develop a simple color-based test that can be done in the physician office or by the parents,” said Dr. Gozal.
References:
1. David Gozal, et al. Two-Dimensional Differential In-Gel Electrophoresis Proteomic Approaches Reveal Urine Candidate Biomarkers in Pediatric Obstructive Sleep Apnea. Am. J. Respir. Crit. Care Med., Dec 2009; 180: 1253 – 1261.
