A recent in vitro study indicates that IGOB131, a seed extract of the traditional West African food plant Irvingia gabonensis, favorably impacts adipogenesis (the formation of fat or fatty tissue) through a variety of critical metabolic pathways.

This current study was aimed at evaluating the effects of IGOB131 on body weight and associated metabolic parameters in overweight human volunteers.

The study participants comprised of 102 healthy, overweight and/or obese volunteers randomly divided into two groups. The groups received on a daily basis, either 150 mg of IGOB131 or matching placebo in a double-blinded fashion, 30–60 minutes before lunch and dinner. At baseline, 4, 8 and 10 weeks of the study, subjects were evaluated for changes in anthropometrics and metabolic parameters to include fasting lipids, blood glucose, C-reactive protein, adiponectin, and leptin.

Significant improvements in body weight, body fat, and waist circumference as well as plasma total cholesterol, LDL cholesterol, blood glucose, C-reactive protein, adiponectin and leptin levels were observed in the IGOB131 group compared with the placebo group.

Irvingia gabonensis administered 150 mg twice daily before meals to overweight and/or obese human volunteers favorably impacts body weight and a variety of parameters characteristic of the metabolic syndrome. This is the first double blind randomized placebo controlled clinical trial regarding the anti obesity and lipid profile modulating effects of an Irvingia gabonensis extract. Irvingia gabonensis extract may prove to be a useful tool in dealing with the emerging global epidemics of obesity, hyperlipidemia, insulin resistance, and their co-morbid conditions.

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References:
1. Judith L Ngondi et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation. Lipids in Health and Disease 2009, 8:7doi:10.1186/1476-511X-8-7.
2. Image by Department of Crop and Soil Sciences, Cornell University.

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